Mississippi Business Environment Before and After Katrina: Challenges and Opportunities

Valid, reliable, and, most importantly, timely information is the most critical aspect for the design and implementation of successful emergency management strategies. This goal, however, is rarely achieved during the aftermath of a disaster. In this paper, we showcase how we used administrative records to assist Mississippi in evaluating the overall impact of Katrina on the state’s economy. Specifically, we assisted the state in developing a methodology to generate valid, reliable, and timely information on (1) the business environment and labor market and (2) rehiring and hiring practices. This information was used by the state to design recovery strategies and justify the necessary funds from federal agencies to assist local communities in their economic recovery. The experience of Mississippi clearly shows that valid, reliable, and timely information is critical for developing effective policy

Social Capital, Structural Conditions, and Mortality: A Study of Nonmetropolitan Counties in Mississippi

In this study, we examine the extent to which structural conditions that favor investment in social capital affect mortality across nonmetro counties in Mississippi. To this end, we focus on four county structural conditions: (1) place of residence within county boundaries, (2) civic infrastructure, (3) economic conditions, and (4) county regional location. The results clearly indicate that structural conditions that favor investment in social capital lead to lower mortality. Specifically, concentration of disadvantage conditions has an independent effect on mortality. That is, its effect operates independentIy of other structural conditions. In contrast, the effects of place of residence and civic infrastructure do not operate independently from county economic conditions. The results also indicate that county regional location has no effect on mortality across nonmetro counties in Mississippi

TANF/Welfare Client Decline and Community Context in the Rural South, 1997-2000

This article examines the extent to which declines in welfare rolls relate to five major dimensions of community: (1) local demographic composition, (2) local labor market conditions, (3) local civic capacity, (4) local spatial characteristics, and (5) changes in local economic opportunities. Results based on data from the Mississippi Department of Human Services indicate that demographically, economically, and socially advantaged communities were more likely to experience high declines in welfare rolls. Rurality was associated with lower likelihood of high declines in welfare rolls across Mississippi counties. Clearly, a combination of a stronger local economy and social support in a local area increases the likelihood of larger decline in welfare rolls. The analysis presented in this article suggests that there is substantial local variation in the decline in welfare rolls that is associated with local economic and social conditions. The success of welfare reform policies clearly hinge on local conditions. What this analysis cannot reveal is the extent to which decline in welfare rolls is the result of recipients marrying, finding good jobs, or simply running up against time limits imposed by the welfare reform legislation

The Proteasome Distinguishes between Heterotypic and Homotypic Lysine-11-Linked Polyubiquitin Chains.

Proteasome-mediated degradation occurs with proteins principally modified with lysine-48 polyubiquitin chains. Whether the proteasome also can bind atypical ubiquitin chains, including those linked by lysine-11, has not been well established. This is critically important, as lysine-11 polyubiquitination has been implicated in both proteasome-mediated degradation and non-degradative outcomes. Here we demonstrate that pure homotypic lysine-11-linked chains do not bind strongly to the mammalian proteasome. By contrast, heterotypic polyubiquitin chains, containing lysine-11 and lysine-48 linkages, not only bind to the proteasome but also stimulate the proteasomal degradation of the cell-cycle regulator cyclin B1. Thus, while heterotypic lysine-11-linked chains facilitate proteasomal degradation, homotypic lysine-11 linkages adopt conformations that prevent association with the proteasome. Our data demonstrate the capacity of the proteasome to bind ubiquitin chains of distinct topology, with implications for the recognition and diverse biological functions of mixed ubiquitin chains.This work is supported by a Wellcome Trust Senior Clinical Research Fellowship to JAN (102770/Z/13/Z), a Wellcome Trust Fellowship to MPW (093966/Z/10/Z) and a National Institute of Health grant (GM067945) to SPG. The Cambridge Institutefor Medical Research is in receipt of a Wellcome Trust Strategic Award [100140].This is the final version of the article. It first appeared from Elsevier via http://dx.doi.org/10.1016/j.celrep.2015.06.06

Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyper-activity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette syndrome. Genetic correlation analyses revealed a meaningful structure within the eight disorders, identifying three groups of inter-related disorders. Meta-analysis across these eight disorders detected 109 loci associated with at least two psychiatric disorders, including 23 loci with pleiotropic effects on four or more disorders and 11 loci with antagonistic effects on multiple disorders. The pleiotropic loci are located within genes that show heightened expression in the brain throughout the lifespan, beginning prenatally in the second trimester, and play prominent roles in neurodevelopmental processes. These findings have important implications for psychiatric nosology, drug development, and risk prediction.Peer reviewe

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Pragmatic Maxims and Presumptions in Legal Interpretation

The fields of linguistic pragmatics and legal interpretation are deeply interrelated. The purpose of this paper is to show how pragmatics and the developments in argumentation theory can contribute to the debate on legal interpretation. The relation between the pragmatic maxims and the presumptions underlying the legal canons are brought to light, unveiling the principles that underlie the types of argument usually used to justify a construction. The Gricean maxims and the arguments of legal interpretation are regarded as presumptions subject to default used to justify an interpretation. This approach can allow one to trace the different legal interpretive arguments back to their basic underlying presumptions, so that they can be compared, ordered, and assessed according to their defeasibility conditions. This approach allows one to understand the difference between various types of interpretive canons, and their strength in justifying an interpretation

Racial Segregation in Rural & Small Town America: Does New York State fit the national pattern?

CaRDI Research & Policy Brief Issue 1